학술논문
Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death
Document Type
article
Author
Jerry H. Houl; Zu Ye; Chris A. Brosey; Lakshitha P. F. Balapiti-Modarage; Sarita Namjoshi; Albino Bacolla; Daniel Laverty; Brian L. Walker; Yasin Pourfarjam; Leslie S. Warden; Naga Babu Chinnam; Davide Moiani; Roderick A. Stegeman; Mei-Kuang Chen; Mien-Chie Hung; Zachary D. Nagel; Tom Ellenberger; In-Kwon Kim; Darin E. Jones; Zamal Ahmed; John A. Tainer
Source
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
PARG catalyzes the removal of poly(ADP-ribose) (PAR) from target proteins and executes critical functions in the DNA damage response. Here the authors provide structural and biological insight with small molecule PARG inhibitors and show that PARG inhibition sensitizes cells to ionizing radiation and kills cancer cells through replication fork defects.