학술논문
An epigenome-wide analysis of cord blood DNA methylation reveals sex-specific effect of exposure to bisphenol A
Document Type
article
Author
Source
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Subject
Language
English
ISSN
2045-2322
Abstract
Abstract Exposure to bisphenol A (BPA) in utero is associated with adverse health outcome of the offspring. Differential DNA methylation at specific CpG sites may link BPA exposure to health impacts. We examined the association of prenatal BPA exposure with genome-wide DNA methylation changes in cord blood in 277 mother-child pairs in the Hokkaido Study on Environment and Children’s Health, using the Illumina HumanMethylation 450 BeadChip. We observed that a large portion of BPA-associated differentially methylated CpGs with p-value