학술논문
Act1 is a negative regulator in T and B cells via direct inhibition of STAT3
Document Type
article
Author
Cun-Jin Zhang; Chenhui Wang; Meiling Jiang; Chunfang Gu; Jianxin Xiao; Xing Chen; Bradley N. Martin; Fangqiang Tang; Erin Yamamoto; Yibo Xian; Han Wang; Fengling Li; R. Balfour Sartor; Howard Smith; M. Elaine Husni; Fu-Dong Shi; Ji Gao; Julie Carman; Ashok Dongre; Susan C. McKarns; Ken Coppieters; Trine N. Jørgensen; Warren J. Leonard; Xiaoxia Li
Source
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
Adaptor for IL-17 receptors (Act1) is known to be crucial for IL-17-mediated immune responses. Here the authors show that Act1 also functions as a negative regulator of T and B cells by direct inhibition of STAT3.