학술논문
Adjuvant-dependent impact of inactivated SARS-CoV-2 vaccines during heterologous infection by a SARS-related coronavirus
Document Type
article
Author
Jacob A. Dillard; Sharon A. Taft-Benz; Audrey C. Knight; Elizabeth J. Anderson; Katia D. Pressey; Breantié Parotti; Sabian A. Martinez; Jennifer L. Diaz; Sanjay Sarkar; Emily A. Madden; Gabriela De la Cruz; Lily E. Adams; Kenneth H. Dinnon; Sarah R. Leist; David R. Martinez; Alexandra Schäfer; John M. Powers; Boyd L. Yount; Izabella N. Castillo; Noah L. Morales; Jane Burdick; Mia Katrina D. Evangelista; Lauren M. Ralph; Nicholas C. Pankow; Colton L. Linnertz; Premkumar Lakshmanane; Stephanie A. Montgomery; Martin T. Ferris; Ralph S. Baric; Victoria K. Baxter; Mark T. Heise
Source
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Subject
Language
English
ISSN
2041-1723
Abstract
Abstract Whole virus-based inactivated SARS-CoV-2 vaccines adjuvanted with aluminum hydroxide have been critical to the COVID-19 pandemic response. Although these vaccines are protective against homologous coronavirus infection, the emergence of novel variants and the presence of large zoonotic reservoirs harboring novel heterologous coronaviruses provide significant opportunities for vaccine breakthrough, which raises the risk of adverse outcomes like vaccine-associated enhanced respiratory disease. Here, we use a female mouse model of coronavirus disease to evaluate inactivated vaccine performance against either homologous challenge with SARS-CoV-2 or heterologous challenge with a bat-derived coronavirus that represents a potential emerging disease threat. We show that inactivated SARS-CoV-2 vaccines adjuvanted with aluminum hydroxide can cause enhanced respiratory disease during heterologous infection, while use of an alternative adjuvant does not drive disease and promotes heterologous viral clearance. In this work, we highlight the impact of adjuvant selection on inactivated vaccine safety and efficacy against heterologous coronavirus infection.