학술논문
Treatment with Umbilical Cord Blood Platelet Lysate Gel Improves Healing of Diabetic Foot Ulcer
Document Type
article
Author
Vaia Lambadiari; Aikaterini Kountouri; Fοteini Psahoulia; Georgia-Angeliki Koliou; Andreas Lazaris; Efstathios Michalopoulos; Panagiotis Mallis; Emmanouil Korakas; Ioanna Eleftheriadou; Konstantinos Balampanis; Markos Sarris; Panagiotis Tsirigotis; George Geroulakos; Catherine Stavropoulos-Giokas; George D. Dimitriadis; Nikolaos Tentolouris
Source
Journal of Clinical Medicine, Vol 13, Iss 5, p 1310 (2024)
Subject
Language
English
ISSN
2077-0383
Abstract
Background: This study was conducted to examine the hypothesis that umbilical cord blood platelet lysate (UCB-PL) gel has a significant impact on the healing rate of DFU. Μethods: In this open-labeled, randomized controlled trial, 110 patients were randomized to treatment with UCB-PL gel (UCB-PL group, n = 52) every three days for one month or dressing with normal saline (control group, n = 58). All participants were followed up for 20 weeks post treatment. Ulcer surface area was assessed with the imitoMeasure application at two, four, and six weeks, and two, four and six months. This study’s main outcome was the reduction in ulcer size over the six-month study period. Results: The mean ulcer area at baseline was 4.1 cm2 in the UCB-PL group and 1.7 cm2 in the control group. At six months post treatment, patients on the UCB-PL treatment displayed a significant reduction in ulcer size compared to baseline 0.12 (0–8.16) in contrast to a more modest change in the control group 1.05 (0–24.7). The ulcer area was decreased at the end of the study in 40 patients (97.6%) in the UCB-PL group and 27 (73%) in the control group (Fisher’s p = 0.002). Conclusions: The application of UCB-PL gel in DFU resulted in a significant reduction in ulcer size compared to regular saline dressing.