학술논문
TREC mediated oncogenesis in human immature T lymphoid malignancies preferentially involves ZFP36L2
Document Type
article
Author
Estelle Balducci; Thomas Steimlé; Charlotte Smith; Patrick Villarese; Mélanie Feroul; Dominique Payet-Bornet; Sophie Kaltenbach; Lucile Couronné; Ludovic Lhermitte; Aurore Touzart; Marie-Emilie Dourthe; Mathieu Simonin; André Baruchel; Hervé Dombret; Norbert Ifrah; Nicolas Boissel; Bertrand Nadel; Elizabeth Macintyre; Agata Cieslak; Vahid Asnafi
Source
Molecular Cancer, Vol 22, Iss 1, Pp 1-6 (2023)
Subject
Language
English
ISSN
1476-4598
Abstract
Abstract The reintegration of excised signal joints resulting from human V(D)J recombination was described as a potent source of genomic instability in human lymphoid cancers. However, such molecular events have not been recurrently reported in clinical patient lymphoma/leukemia samples. Using a specifically designed NGS-capture pipeline, we here demonstrated the reintegration of T-cell receptor excision circles (TRECs) in 20/1533 (1.3%) patients with T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL). Remarkably, the reintegration of TREC recurrently targeted the tumor suppressor gene, ZFP36L2, in 17/20 samples. Thus, our data identified a new and hardly detectable mechanism of gene deregulation in lymphoid cancers providing new insights in human oncogenesis.