학술논문
Causal association between snoring and stroke: a Mendelian randomization study in a Chinese populationResearch in context
Document Type
article
Author
Yunqing Zhu; Zhenhuang Zhuang; Jun Lv; Dianjianyi Sun; Pei Pei; Ling Yang; Iona Y. Millwood; Robin G. Walters; Yiping Chen; Huaidong Du; Xianping Wu; Dan Schmidt; Daniel Avery; Junshi Chen; Zhengming Chen; Liming Li; Canqing Yu; Robert Clarke; Rory Collins; Yu Guo; Richard Peto; Robin Walter; Derrick Bennett; Ruth Boxall; Sue Burgess; Ka Hung Chan; Yumei Chang; Johnathan Clarke; Ahmed Edris Mohamed; Zammy Fairhurst-Hunter; Hannah Fry; Mike Hill; Michael Holmes; Pek Kei Im; Andri Iona; Maria Kakkoura; Christiana Kartsonaki; Rene Kerosi; Kuang Lin; Mohsen Mazidi; Iona Millwood; Sam Morris; Qunhua Nie; Alfred Pozarickij; Paul Ryder; Saredo Said; Paul Sherliker; Becky Stevens; Iain Turnbull; Robin Walters; Lin Wang; Neil Wright; Xiaoming Yang; Pang Yao; Xiao Han; Can Hou; Chao Liu; Qingmei Xia; Zengchang Pang; Ruqin Gao; Shanpeng Li; Haiping Duan; Shaojie Wang; Yongmei Liu; Ranran Du; Yajing Zang; Liang Cheng; Xiaocao Tian; Hua Zhang; Yaoming Zhai; Feng Ning; Xiaohui Sun; Feifei Li; Silu Lv; Junzheng Wang; Wei Hou; Wei Sun; Shichun Yan; Xiaoming Cui; Chi Wang; Zhenyuan Wu; Yanjie Li; Quan Kang; Huiming Luo; Tingting Ou; Xiangyang Zheng; Zhendong Guo; Shukuan Wu; Yilei Li; Huimei Li; Ming Wu; Yonglin Zhou; Jinyi Zhou; Ran Tao; Jie Yang; Jian Su; Fang Liu; Jun Zhang; Yihe Hu; Yan Lu; Liangcai Ma; Aiyu Tang; Shuo Zhang; Jianrong Jin; Jingchao Liu; Mei Lin; Zhenzhen Lu; Lifang Zhou; Changping Xie; Jian Lan; Tingping Zhu; Yun Liu; Liuping Wei; Liyuan Zhou; Ningyu Chen; Yulu Qin; Sisi Wang; Ningmei Zhang; Xiaofang Chen; Xiaoyu Chang; Mingqiang Yuan; Xia Wu; Wei Jiang; Jiaqiu Liu; Qiang Sun; Faqing Chen; Xiaolan Ren; Caixia Dong; Hui Zhang; Enke Mao; Xiaoping Wang; Tao Wang; Xi zhang; Kai Kang; Shixian Feng; Huizi Tian; Lei Fan; XiaoLin Li; Huarong Sun; Pan He; Xukui Zhang; Min Yu; Ruying Hu; Hao Wang; Xiaoyi Zhang; Yuan Cao; Kaixu Xie; Lingli Chen; Dun Shen; Xiaojun Li; Donghui Jin; Li Yin; Huilin Liu; Zhongxi Fu; Xin Xu; Hao Zhang; Jianwei Chen; Yuan Peng; Libo Zhang; Chan Qu
Source
The Lancet Regional Health. Western Pacific, Vol 44, Iss , Pp 101001- (2024)
Subject
Language
English
ISSN
2666-6065
Abstract
Summary: Background: Previous observational studies established a positive relationship between snoring and stroke. We aimed to investigate the causal effect of snoring on stroke. Methods: Based on 82,339 unrelated individuals with qualified genotyping data of Asian descent from the China Kadoorie Biobank (CKB), we conducted a Mendelian randomization (MR) analysis of snoring and stroke. Genetic variants identified in the genome-wide association analysis (GWAS) of snoring in CKB and UK Biobank (UKB) were selected for constructing genetic risk scores (GRS). A two-stage method was applied to estimate the associations of the genetically predicted snoring with stroke and its subtypes. Besides, MR analysis among the non-obese group (body mass index, BMI