학술논문
Is elective neck dissection justified in cT2N0M0 oral cavity cancer defined according to the AJCC eighth edition staging system?
Document Type
article
Author
Tsung‐Ming Chen; Shyuang‐Der Terng; Li‐Yu Lee; Shu‐Ru Lee; Shu‐Hang Ng; Chung‐Jan Kang; Jin‐Ching Lin; Chih‐Yen Chien; Chun‐Hung Hua; Cheng Ping Wang; Wen‐Cheng Chen; Yao‐Te Tsai; Chi‐Ying Tsai; Chien‐Yu Lin; Kang‐Hsing Fan; Hung‐Ming Wang; Chia‐Hsun Hsieh; Chih‐Hua Yeh; Chih‐Hung Lin; Chung‐Kan Tsao; Nai‐Ming Cheng; Tuan‐Jen Fang; Shiang‐Fu Huang; Li‐Ang Lee; Ku‐Hao Fang; Yu‐Chien Wang; Wan‐Ni Lin; Li‐Jen Hsin; Tzu‐Chen Yen; Yu‐Wen Wen; Chun‐Ta Liao
Source
Cancer Medicine, Vol 13, Iss 1, Pp n/a-n/a (2024)
Subject
Language
English
ISSN
2045-7634
Abstract
Abstract Background The current NCCN guidelines recommend considering elective neck dissection (END) for early‐stage oral cavity squamous cell carcinoma (OCSCC) with a depth of invasion (DOI) exceeding 3 mm. However, this DOI threshold, determined by evaluating the occult lymph node metastatic rate, lacks robust supporting evidence regarding its impact on patient outcomes. In this nationwide study, we sought to explore the specific indications for END in patients diagnosed with OCSCC at stage cT2N0M0, as defined by the AJCC Eighth Edition staging criteria. Methods We examined 4723 patients with cT2N0M0 OCSCC, of which 3744 underwent END and 979 were monitored through neck observation (NO). Results Patients who underwent END had better 5‐year outcomes compared to those in the NO group. The END group had higher rates of neck control (95% vs. 84%, p