학술논문
Circulating AQP4 Levels in Patients with Cerebral Amyloid Angiopathy-Associated Intracerebral Hemorrhage
Document Type
article
Author
Paula Marazuela; Anna Bonaterra-Pastra; Júlia Faura; Anna Penalba; Jesús Pizarro; Olalla Pancorbo; David Rodríguez-Luna; Carla Vert; Alex Rovira; Francesc Pujadas; M. Mar Freijo; Silvia Tur; Maite Martínez-Zabaleta; Pere Cardona Portela; Rocío Vera; Lucia Lebrato-Hernández; Juan F. Arenillas; Soledad Pérez-Sánchez; Joan Montaner; Pilar Delgado; Mar Hernández-Guillamon
Source
Journal of Clinical Medicine, Vol 10, Iss 5, p 989 (2021)
Subject
Language
English
ISSN
2077-0383
Abstract
Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage (ICH) in elderly patients. Growing evidence suggests a potential role of aquaporin 4 (AQP4) in amyloid-beta-associated diseases, including CAA pathology. Our aim was to investigate the circulating levels of AQP4 in a cohort of patients who had suffered a lobar ICH with a clinical diagnosis of CAA. AQP4 levels were analyzed in the serum of 60 CAA-related ICH patients and 19 non-stroke subjects by enzyme-linked immunosorbent assay (ELISA). The CAA–ICH cohort was divided according to the time point of the functional outcome evaluation: mid-term (12 ± 18.6 months) and long-term (38.5 ± 32.9 months) after the last ICH. Although no differences were found in AQP4 serum levels between cases and controls, lower levels were found in CAA patients presenting specific hemorrhagic features such as ≥2 lobar ICHs and ≥5 lobar microbleeds detected by magnetic resonance imaging (MRI). In addition, CAA-related ICH patients who presented a long-term good functional outcome had higher circulating AQP4 levels than subjects with a poor outcome or controls. Our data suggest that AQP4 could potentially predict a long-term functional outcome and may play a protective role after a lobar ICH.