학술논문
Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control study
Document Type
article
Author
F. Balazard; S. Le Fur; S. Valtat; A. J. Valleron; P. Bougnères; Isis-Diab collaborative group; Dominique Thevenieau; Corinne Fourmy Chatel; Rachel Desailloud; Hélène Bony-Trifunovic; Pierre-Henri Ducluzeau; Régis Coutant; Sophie Caudrelier; Armelle Pambou; Emmanuelle Dubosclard; Florence Joubert; Philippe Jan; Estelle Marcoux; Anne-Marie Bertrand; Brigitte Mignot; Alfred Penformis; Chantal Stuckens; Régis Piquemal; Pascal Barat; Vincent Rigalleau; Chantal Stheneur; Sylviane Fournier; Véronique Kerlan; Chantal Metz; Anne Fargeot-Espaliat; Yves Reznic; Frédérique Olivier; Iva Gueorguieva; Arnaud Monier; Catherine Radet; Vincent Gajdos; Daniel Terral; Christine Vervel; Djamel Bendifallah; Candace Ben Signor; Daniel Dervaux; Abdelkader Benmahammed; Guy-André Loeuille; Françoise Popelard; Agnès Guillou; Pierre-Yves Benhamou; Jamil Khoury; Jean-Pierre Brossier; Joachim Bassil; Sylvaine Clavel; Bernard Le Luyer; Pierre Bougnères; Françoise Labay; Isabelle Guemas; Jacques Weill; Jean-Pierre Cappoen; Sylvie Nadalon; Anne Lienhardt-Roussie; Anne Paoli; Claudie Kerouedan; Edwige Yollin; Marc Nicolino; Gilbert Simonin; Jacques Cohen; Catherine Atlan; Agnès Tamboura; Hervé Dubourg; Marie-Laure Pignol; Philippe Talon; Stéphanie Jellimann; Lucy Chaillous; Sabine Baron; Marie-Noëlle Bortoluzzi; Elisabeth Baechler; Randa Salet; Ariane Zelinsky-Gurung; Fabienne Dallavale; Etienne Larger; Marie Laloi-Michelin; Jean-François Gautier; Bénédicte Guérin; Laure Oilleau; Laetitia Pantalone; Céline Lukas; Isabelle Guilhem; Marc De Kerdanet; Marie-Claire Wielickzo; Mélanie Priou-Guesdon; Odile Richard; François Kurtz; Norbert Laisney; Déborah Ancelle; Guilhem Parlier; Catherine Boniface; Dominique Paris Bockel; Denis Dufillot; Berthe Razafimahefa; Pierre Gourdy; Pierre Lecomte; Myriam Pepin-Donat; Marie-Emmanuelle Combes-Moukhovsky; Brigitte Zymmermann; Marina Raoulx; Anne Gourdin et Catherine Dumont
Source
BMC Public Health, Vol 16, Iss 1, Pp 1-10 (2016)
Subject
Language
English
ISSN
1471-2458
Abstract
Abstract Background The incidence of childhood type 1 diabetes (T1D) incidence is rising in many countries, supposedly because of changing environmental factors, which are yet largely unknown. The purpose of the study was to unravel environmental markers associated with T1D. Methods Cases were children with T1D from the French Isis-Diab cohort. Controls were schoolmates or friends of the patients. Parents were asked to fill a 845-item questionnaire investigating the child’s environment before diagnosis. The analysis took into account the matching between cases and controls. A second analysis used propensity score methods. Results We found a negative association of several lifestyle variables, gastroenteritis episodes, dental hygiene, hazelnut cocoa spread consumption, wasp and bee stings with T1D, consumption of vegetables from a farm and death of a pet by old age. Conclusions The found statistical association of new environmental markers with T1D calls for replication in other cohorts and investigation of new environmental areas. Trial registration Clinical-Trial.gov NCT02212522 . Registered August 6, 2014.