부산대학교 도서관

Background: Dietary and nutrient intake is an important factor in the development and management of non-alcoholic fatty liver disease (NAFLD) however, optimal dietary and nutrient composition remains unclear. Data on detailed nutrient intake of NAFLD patients from India is scarce. There are no studies on the relationship between nutrient intake and markers of liver health (liver fibrosis and liver steatosis) in Indian adults diagnosed with NAFLD. Objectives: The objectives of this study were to (i) Assess the intake of macro and micro nutrients between NAFLD Cases and Controls (ii) to compare the nutrient intake of adult participants with the EAR (Estimated Average Requirements for Indians) (2020) (iii) to study the association of nutrients with NAFLD (iv) to explore the relationships between select nutrients and markers of metabolic and liver health (liver fibrosis and liver steatosis). Methods & materials: 160 NAFLD Cases and 160 Controls (n = 320) from Gastro and Medicine OPD of AIIMS hospital were recruited for the study.24 h nutrient intake for 2 days, anthropometrics, blood biomarkers. Fibro scan to study both hepatic fibrosis and steatosis was undertaken to assess Liver stiffness measurement (LSM) and Controlled attenuation parameter (CAP score).Nutrient intake was compared with EAR 2020 for Indians. Association between NAFLD and nutrient intake was done by logistic regression. Results: The NAFLD Cases showed significantly higher amounts of SFA(g), percent SFA (%), PUFA(g), percent PUFA (%), n6 (g) and n6/n3 ratio compared to controls (p 8% of the total calories. Significant inverse association of percent proteins (5–15%) with NAFLD was observed(p