학술논문
Epigenome-wide meta-analysis identifies DNA methylation biomarkers associated with diabetic kidney disease
Document Type
article
Author
Laura J. Smyth; Emma H. Dahlström; Anna Syreeni; Katie Kerr; Jill Kilner; Ross Doyle; Eoin Brennan; Viji Nair; Damian Fermin; Robert G. Nelson; Helen C. Looker; Christopher Wooster; Darrell Andrews; Kerry Anderson; Gareth J. McKay; Joanne B. Cole; Rany M. Salem; Peter J. Conlon; Matthias Kretzler; Joel N. Hirschhorn; Denise Sadlier; Catherine Godson; Jose C. Florez; GENIE consortium; Carol Forsblom; Alexander P. Maxwell; Per-Henrik Groop; Niina Sandholm; Amy Jayne McKnight
Source
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Approximately 40 percent of people with type 1 diabetes develop kidney disease, but the risk factors are not well understood. Here, the authors identify DNA methylation signatures associated with diabetic kidney disease, of which 21 biomarkers predict the development of kidney failure.