학술논문
Phenotyping asthma with airflow obstruction in middle-aged and older adults: a CADSET clinical research collaboration
Document Type
article
Author
Judith M Vonk; Torben Sigsgaard; Kian Fan Chung; Lies Lahousse; Maarten van den Berge; Jadwiga A Wedzicha; Judith Garcia-Aymerich; Anne Lindberg; Claus Vogelmeier; Helena Backman; Eva Rönmark; Ian M Adcock; Peter Alter; Alvar Agustí; Gavin C Donaldson; Guy G Brusselle; Rosa Faner; Howraman Meteran; Ahmed Edris; Nazanin Zounemat Kermani; Xander Bertels; Nuria Olvera
Source
BMJ Open Respiratory Research, Vol 10, Iss 1 (2023)
Subject
Language
English
ISSN
2052-4439
Abstract
Background The prevalence and clinical profile of asthma with airflow obstruction (AO) remain uncertain. We aimed to phenotype AO in population- and clinic-based cohorts.Methods This cross-sectional multicohort study included adults ≥50 years from nine CADSET cohorts with spirometry data (N=69 789). AO was defined as ever diagnosed asthma with pre-BD or post-BD FEV1/FVC 300 cells/µL), although only significant in population-based cohorts. Compared with asthma-only, AO patients were more often men, current smokers, with a lower BMI, had less often obesity and had more often chronic bronchitis. Compared with COPD-only, AO patients were younger, less often current smokers and had less pack-years. In the general population, AO patients had a higher risk of coronary artery disease than asthma-only and COPD-only (OR=2.09 (95% CI 1.26 to 3.47) and OR=1.89 (95% CI 1.10 to 3.24), respectively) and of depression (OR=1.41 (95% CI 1.19 to 1.67)), osteoporosis (OR=2.30 (95% CI 1.43 to 3.72)) and gastro-oesophageal reflux disease (OR=1.68 (95% CI 1.06 to 2.68)) than COPD-only, independent of age, sex, smoking status and BMI.Conclusions AO is a relatively prevalent respiratory phenotype associated with more dyspnoea and a higher risk of coronary artery disease and elevated blood eosinophil counts in the general population compared with both asthma-only and COPD-only.