학술논문
Knowledge-guided analysis of 'omics' data using the KnowEnG cloud platform.
Document Type
article
Author
Charles Blatti; Amin Emad; Matthew J Berry; Lisa Gatzke; Milt Epstein; Daniel Lanier; Pramod Rizal; Jing Ge; Xiaoxia Liao; Omar Sobh; Mike Lambert; Corey S Post; Jinfeng Xiao; Peter Groves; Aidan T Epstein; Xi Chen; Subhashini Srinivasan; Erik Lehnert; Krishna R Kalari; Liewei Wang; Richard M Weinshilboum; Jun S Song; C Victor Jongeneel; Jiawei Han; Umberto Ravaioli; Nahil Sobh; Colleen B Bushell; Saurabh Sinha
Source
PLoS Biology, Vol 18, Iss 1, p e3000583 (2020)
Subject
Language
English
ISSN
1544-9173
1545-7885
1545-7885
Abstract
We present Knowledge Engine for Genomics (KnowEnG), a free-to-use computational system for analysis of genomics data sets, designed to accelerate biomedical discovery. It includes tools for popular bioinformatics tasks such as gene prioritization, sample clustering, gene set analysis, and expression signature analysis. The system specializes in "knowledge-guided" data mining and machine learning algorithms, in which user-provided data are analyzed in light of prior information about genes, aggregated from numerous knowledge bases and encoded in a massive "Knowledge Network." KnowEnG adheres to "FAIR" principles (findable, accessible, interoperable, and reuseable): its tools are easily portable to diverse computing environments, run on the cloud for scalable and cost-effective execution, and are interoperable with other computing platforms. The analysis tools are made available through multiple access modes, including a web portal with specialized visualization modules. We demonstrate the KnowEnG system's potential value in democratization of advanced tools for the modern genomics era through several case studies that use its tools to recreate and expand upon the published analysis of cancer data sets.