학술논문
Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
Document Type
article
Author
M. Carola Zillikens; Serkalem Demissie; Yi-Hsiang Hsu; Laura M. Yerges-Armstrong; Wen-Chi Chou; Lisette Stolk; Gregory Livshits; Linda Broer; Toby Johnson; Daniel L. Koller; Zoltán Kutalik; Jian’an Luan; Ida Malkin; Janina S. Ried; Albert V. Smith; Gudmar Thorleifsson; Liesbeth Vandenput; Jing Hua Zhao; Weihua Zhang; Ali Aghdassi; Kristina Åkesson; Najaf Amin; Leslie J. Baier; Inês Barroso; David A. Bennett; Lars Bertram; Rainer Biffar; Murielle Bochud; Michael Boehnke; Ingrid B. Borecki; Aron S. Buchman; Liisa Byberg; Harry Campbell; Natalia Campos Obanda; Jane A. Cauley; Peggy M. Cawthon; Henna Cederberg; Zhao Chen; Nam H. Cho; Hyung Jin Choi; Melina Claussnitzer; Francis Collins; Steven R. Cummings; Philip L. De Jager; Ilja Demuth; Rosalie A. M. Dhonukshe-Rutten; Luda Diatchenko; Gudny Eiriksdottir; Anke W. Enneman; Mike Erdos; Johan G. Eriksson; Joel Eriksson; Karol Estrada; Daniel S. Evans; Mary F. Feitosa; Mao Fu; Melissa Garcia; Christian Gieger; Thomas Girke; Nicole L. Glazer; Harald Grallert; Jagvir Grewal; Bok-Ghee Han; Robert L. Hanson; Caroline Hayward; Albert Hofman; Eric P. Hoffman; Georg Homuth; Wen-Chi Hsueh; Monica J. Hubal; Alan Hubbard; Kim M. Huffman; Lise B. Husted; Thomas Illig; Erik Ingelsson; Till Ittermann; John-Olov Jansson; Joanne M. Jordan; Antti Jula; Magnus Karlsson; Kay-Tee Khaw; Tuomas O. Kilpeläinen; Norman Klopp; Jacqueline S. L. Kloth; Heikki A. Koistinen; William E. Kraus; Stephen Kritchevsky; Teemu Kuulasmaa; Johanna Kuusisto; Markku Laakso; Jari Lahti; Thomas Lang; Bente L. Langdahl; Lenore J. Launer; Jong-Young Lee; Markus M. Lerch; Joshua R. Lewis; Lars Lind; Cecilia Lindgren; Yongmei Liu; Tian Liu; Youfang Liu; Östen Ljunggren; Mattias Lorentzon; Robert N. Luben; William Maixner; Fiona E. McGuigan; Carolina Medina-Gomez; Thomas Meitinger; Håkan Melhus; Dan Mellström; Simon Melov; Karl Michaëlsson; Braxton D. Mitchell; Andrew P. Morris; Leif Mosekilde; Anne Newman; Carrie M. Nielson; Jeffrey R. O’Connell; Ben A. Oostra; Eric S. Orwoll; Aarno Palotie; Stephen C. J. Parker; Munro Peacock; Markus Perola; Annette Peters; Ozren Polasek; Richard L. Prince; Katri Räikkönen; Stuart H. Ralston; Samuli Ripatti; John A. Robbins; Jerome I. Rotter; Igor Rudan; Veikko Salomaa; Suzanne Satterfield; Eric E. Schadt; Sabine Schipf; Laura Scott; Joban Sehmi; Jian Shen; Chan Soo Shin; Gunnar Sigurdsson; Shad Smith; Nicole Soranzo; Alena Stančáková; Elisabeth Steinhagen-Thiessen; Elizabeth A. Streeten; Unnur Styrkarsdottir; Karin M. A. Swart; Sian-Tsung Tan; Mark A. Tarnopolsky; Patricia Thompson; Cynthia A. Thomson; Unnur Thorsteinsdottir; Emmi Tikkanen; Gregory J. Tranah; Jaakko Tuomilehto; Natasja M. van Schoor; Arjun Verma; Peter Vollenweider; Henry Völzke; Jean Wactawski-Wende; Mark Walker; Michael N. Weedon; Ryan Welch; H.-Erich Wichmann; Elisabeth Widen; Frances M. K. Williams; James F. Wilson; Nicole C. Wright; Weijia Xie; Lei Yu; Yanhua Zhou; John C. Chambers; Angela Döring; Cornelia M. van Duijn; Michael J. Econs; Vilmundur Gudnason; Jaspal S. Kooner; Bruce M. Psaty; Timothy D. Spector; Kari Stefansson; Fernando Rivadeneira; André G. Uitterlinden; Nicholas J. Wareham; Vicky Ossowski; Dawn Waterworth; Ruth J. F. Loos; David Karasik; Tamara B. Harris; Claes Ohlsson; Douglas P. Kiel
Source
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Subject
Language
English
ISSN
2041-1723
Abstract
Lean body mass is a highly heritable trait and is associated with various health conditions. Here, Kiel and colleagues perform a meta-analysis of genome-wide association studies for whole body lean body mass and find five novel genetic loci to be significantly associated.