학술논문
Deep phenotyping and lifetime trajectories reveal limited effects of longevity regulators on the aging process in C57BL/6J mice
Document Type
article
Author
Kan Xie; Helmut Fuchs; Enzo Scifo; Dan Liu; Ahmad Aziz; Juan Antonio Aguilar-Pimentel; Oana Veronica Amarie; Lore Becker; Patricia da Silva-Buttkus; Julia Calzada-Wack; Yi-Li Cho; Yushuang Deng; A. Cole Edwards; Lillian Garrett; Christina Georgopoulou; Raffaele Gerlini; Sabine M. Hölter; Tanja Klein-Rodewald; Michael Kramer; Stefanie Leuchtenberger; Dimitra Lountzi; Phillip Mayer-Kuckuk; Lena L. Nover; Manuela A. Oestereicher; Clemens Overkott; Brandon L. Pearson; Birgit Rathkolb; Jan Rozman; Jenny Russ; Kristina Schaaf; Nadine Spielmann; Adrián Sanz-Moreno; Claudia Stoeger; Irina Treise; Daniele Bano; Dirk H. Busch; Jochen Graw; Martin Klingenspor; Thomas Klopstock; Beverly A. Mock; Paolo Salomoni; Carsten Schmidt-Weber; Marco Weiergräber; Eckhard Wolf; Wolfgang Wurst; Valérie Gailus-Durner; Monique M. B. Breteler; Martin Hrabě de Angelis; Dan Ehninger
Source
Nature Communications, Vol 13, Iss 1, Pp 1-29 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Lifespan can be affected by both physiological ageing and specific sets of pathologies associated with old age. Here the authors report a resource of large-scale cross-sectional phenotyping of aging male mice at different time points to analyse a large set of phenotypes and molecular markers, including during genetic and diet interventions affecting lifespan.