학술논문
Astroblastomas exhibit radial glia stem cell lineages and differential expression of imprinted and X-inactivation escape genes
Document Type
article
Author
Norman L. Lehman; Nathalie Spassky; Müge Sak; Amy Webb; Cory T. Zumbar; Aisulu Usubalieva; Khaled J. Alkhateeb; Joseph P. McElroy; Kirsteen H. Maclean; Paolo Fadda; Tom Liu; Vineela Gangalapudi; Jamie Carver; Zied Abdullaev; Cynthia Timmers; John R. Parker; Christopher R. Pierson; Bret C. Mobley; Murat Gokden; Eyas M. Hattab; Timothy Parrett; Ralph X. Cooke; Trang D. Lehman; Stefan Costinean; Anil Parwani; Brian J. Williams; Randy L. Jensen; Kenneth Aldape; Akshitkumar M. Mistry
Source
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Astroblastoma (AB) is an uncommon brain tumour and its origin remains unknown. Here, the authors perform integrative molecular analysis of 35 AB-like tumours and provide evidence that these arise in the context of epigenetic and genetic changes in neural progenitors occurring during brain development.