학술논문
A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia
Document Type
article
Author
Source
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Identifying leukaemia stem cells (LSC) and defining how they drive tumourigenesis might aid in the treatment of disease. Here, the authors show that a reporter Musashi 2 can serve as a platform to effectively identify leukemic stem cells and it is used to define Syndecan-1 as a dependency for these aggressive, therapy resistant cells.