학술논문
Platelets reduce anoikis and promote metastasis by activating YAP1 signaling
Document Type
article
Author
Monika Haemmerle; Morgan L. Taylor; Tony Gutschner; Sunila Pradeep; Min Soon Cho; Jianting Sheng; Yasmin M. Lyons; Archana S. Nagaraja; Robert L. Dood; Yunfei Wen; Lingegowda S. Mangala; Jean M. Hansen; Rajesha Rupaimoole; Kshipra M. Gharpure; Cristian Rodriguez-Aguayo; Sun Young Yim; Ju-Seog Lee; Cristina Ivan; Wei Hu; Gabriel Lopez-Berestein; Stephen T. Wong; Beth Y. Karlan; Douglas A. Levine; Jinsong Liu; Vahid Afshar-Kharghan; Anil K. Sood
Source
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Subject
Language
English
ISSN
2041-1723
Abstract
Platelets have been associated with increased tumor growth and metastasis but the mechanistic details of this interaction are still unclear. Here the authors show that platelets improve anoikis resistance of cancer cells and increase metastasis by activating Yap through a RhoA/MYPT-PP1 pathway.