학술논문
Durability of per-oral endoscopic myotomy beyond 6 years
Document Type
article
Author
Jad P. AbiMansour; Yervant Ichkhanian; Hitomi Minami; Pietro Familiari; Rosario Landi; Guido Costamagna; Stefan Seewald; Zachary M. Callahan; Michael B. Ujiki; Mathieu Pioche; Thierry Ponchon; Sabine Roman; Joo Young Cho; In Kyung Yoo; Megan Sippey; Jeffrey M. Marks; Nikolas Eleftheriadis; Vivek Khumbari; Olaya I. Brewer Gutierrez; Mouen A. Khashab
Source
Endoscopy International Open, Vol 09, Iss 11, Pp E1595-E1601 (2021)
Subject
Language
English
ISSN
2364-3722
2196-9736
2196-9736
Abstract
Background and study aims The aim of this study was to assess long-term clinical outcomes beyond 6 years in patients who underwent per-oral endoscopic myotomy (POEM) for the treatment of achalasia. Patients and methods Patients with achalasia who underwent POEM between 2010 and 2012 and had follow-up of at least 6 years were retrospectively identified at eight tertiary care centers. The primary outcome evaluated was clinical success defined by an Eckardt symptom score (ESS) ≤ 3 for the duration of the follow-up period. The clinical success cohort was compared to failure (ESS > 3 at any time during follow-up) in order to identify characteristics associated with symptom relapse. The incidence of patient-reported gastroesophageal reflux (GER) was also evaluated. Results Seventy-three patients with 6-year follow-up data were identified. Sustained clinical remission was noted in 89 % (65/73) at 6-years. Mean ESS decreased from 7.1 ± 2.3 pre-procedure to 1.1 ± 1.1 at 6 years (P