학술논문
Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion
Document Type
article
Author
Chrystian Junqueira Alves; Rafael Dariolli; Jonathan Haydak; Sangjo Kang; Theodore Hannah; Robert J. Wiener; Stefanie DeFronzo; Rut Tejero; Gabriele L. Gusella; Aarthi Ramakrishnan; Rodrigo Alves Dias; Alexandre Wojcinski; Santosh Kesari; Li Shen; Eric A. Sobie; José Paulo Rodrigues Furtado de Mendonça; Evren U. Azeloglu; Hongyan Zou; Roland H. Friedel
Source
Nature Communications, Vol 12, Iss 1, Pp 1-23 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Biomechanical mechanisms orchestrating stem cell dynamics in development remain unclear. Here the authors show that guidance receptor Plexin-B2 organizes actomyosin contractility, cytoskeletal tension and adhesion during multicellular development of human embryonic stem cells and neuroprogenitor cells.