학술논문
Effect of continuing versus stopping pre-stroke antihypertensive agents within 12 h on outcome after stroke: A subgroup analysis of the efficacy of nitric oxide in stroke (ENOS) trial
Document Type
article
Author
Lisa J. Woodhouse; Jason P. Appleton; Polly Scutt; Lisa Everton; Gwenllian Wilkinson; Valeria Caso; Anna Czlonkowska; John Gommans; Kailash Krishnan; Ann C. Laska; George Ntaios; Serefnur Ozturk; Stephen Phillips; Stuart Pocock; Kameshwar Prasad; Szabolcs Szatmari; Joanna M. Wardlaw; Nikola Sprigg; Philip M. Bath
Source
EClinicalMedicine, Vol 44, Iss , Pp 101274- (2022)
Subject
Language
English
ISSN
2589-5370
Abstract
Summary: Background: It is not known whether to continue or temporarily stop existing antihypertensive drugs in patients with acute stroke. Methods: We performed a prospective subgroup analysis of patients enrolled into the Efficacy of Nitric Oxide in Stroke (ENOS) trial who were randomised to continue vs stop prior antihypertensive therapy within 12 h of stroke onset. The primary outcome was functional outcome, assessed with the modified Rankin Scale at 90 days by observers blinded to treatment assignment, and analysed with ordinal logistic regression. Findings: Of 4011 patients recruited into ENOS from 2001 to 2014, 2097 patients were randomised to continue vs stop prior antihypertensive treatment, and 384 (18.3%, continue 185, stop 199) were enrolled within 12 h of ictus: mean (SD) age 71.8 (11.8) years, female 193 (50.3%), ischaemic stroke 342 (89.1%) and total anterior circulation syndrome 114 (29.7%). As compared with stopping, continuing treatment within 12 h of onset lowered blood pressure by 15.5/9.6 mmHg (p