학술논문
GPR180 is a component of TGFβ signalling that promotes thermogenic adipocyte function and mediates the metabolic effects of the adipocyte-secreted factor CTHRC1
Document Type
article
Author
Lucia Balazova; Miroslav Balaz; Carla Horvath; Áron Horváth; Caroline Moser; Zuzana Kovanicova; Adhideb Ghosh; Umesh Ghoshdastider; Vissarion Efthymiou; Elke Kiehlmann; Wenfei Sun; Hua Dong; Lianggong Ding; Ez-Zoubir Amri; Pirjo Nuutila; Kirsi A. Virtanen; Tarja Niemi; Barbara Ukropcova; Jozef Ukropec; Pawel Pelczar; Thorsten Lamla; Bradford Hamilton; Heike Neubauer; Christian Wolfrum
Source
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Activation of thermogenic adipocytes is a strategy to combat metabolic diseases. Here the authors report that GPR180 is a component of TGFβ signalling that promotes thermogenic adipocyte function and mediates the metabolic effects of the adipocyte-secreted factor CTHRC1, and contributes to the regulation of glucose and energy metabolism.