학술논문
Predictors of early remission of proteinuria in adult patients with minimal change disease: a retrospective cohort study
Document Type
article
Author
Ryohei Yamamoto; Enyu Imai; Shoichi Maruyama; Hitoshi Yokoyama; Hitoshi Sugiyama; Asami Takeda; Shunya Uchida; Tatsuo Tsukamoto; Kazuhiko Tsuruya; Yasuhiro Akai; Kosaku Nitta; Megumu Fukunaga; Hiroki Hayashi; Kosuke Masutani; Takashi Wada; Tsuneo Konta; Ritsuko Katafuchi; Saori Nishio; Shunsuke Goto; Hirofumi Tamai; Arimasa Shirasaki; Tatsuya Shoji; Kojiro Nagai; Tomoya Nishino; Kunihiro Yamagata; Junichiro J. Kazama; Keiju Hiromura; Hideo Yasuda; Makoto Mizutani; Tomohiko Naruse; Takeyuki Hiramatsu; Kunio Morozumi; Hiroshi Sobajima; Yosuke Saka; Eiji Ishimura; Daisuke Ichikawa; Takashi Shigematsu; Tadashi Sofue; Shouichi Fujimoto; Takafumi Ito; Hiroshi Sato; Ichiei Narita; Yoshitaka Isaka; JNSCS Investigators
Source
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Subject
Language
English
ISSN
2045-2322
Abstract
Abstract Previous studies reported conflicting results regarding an association between serum albumin concentration and the cumulative incidence of remission of proteinuria in adult patients with minimal change disease (MCD). The present study aimed to clarify the clinical impact of serum albumin concentration and the cumulative incidence of remission and relapse of proteinuria in 108 adult patients with MCD at 40 hospitals in Japan, who were enrolled in a 5-year prospective cohort study of primary nephrotic syndrome, the Japan Nephrotic Syndrome Cohort Study (JNSCS). The association between serum albumin concentration before initiation of immunosuppressive treatment (IST) and the cumulative incidence of remission and relapse were assessed using multivariable-adjusted Cox proportional hazards models. Remission defined as urinary protein 1.5 g/dL) showed significantly slow remission. In conclusion, lower serum albumin concentration and higher eGFR were associated with earlier remission in MCD, but not with relapse.