학술논문
Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data
Document Type
article
Author
Rossella Cannarella; Rupin Shah; Taha Abo-Almagd Abdel-Meguid Hamoda; Florence Boitrelle; Ramadan Saleh; Murat Gul; Amarnath Rambhatla; Parviz Kavoussi; Tuncay Toprak; Ahmed M. Harraz; Edmund Ko; Gökhan Çeker; Damayanthi Durairajanayagam; Noora Alkahidi; Shinnosuke Kuroda; Andrea Crafa; Ralf Henkel; Gianmaria Salvio; Berk Hazir; Mahsa Darbandi; Marion Bendayan; Sara Darbandi; Marco Falcone; Raghavender Kosgi; Raneen Sawaid Kaiyal; Keshab Karna; Nguyen Ho Vinh Phuoc; Ponco Birowo; Giovanni M. Colpi; Jean de la Rosette; Germar-Michael Pinggera; Quang Nguyen; Armand Zini; Wael Zohdy; Rajender Singh; Pallavi Saini; Sidney Glina; Haocheng Lin; Taymour Mostafa; Cesar Rojas-Cruz; Mohamed Arafa; Aldo E. Calogero; Fotios Dimitriadis; Priyank Kothari; Vilvapathy Senguttuvan Karthikeyan; Keisuke Okada; Koji Chiba; Ates Kadıoglu; Baris Altay; Tahsin Turunc; Birute Zilaitiene; Fatih Gokalp; Aram Adamyan; Darren Katz; Eric Chung; Tiago Cesar Mierzwa; Daniel Suslik Zylbersztejn; Gustavo Marquesine Paul; Nikolaos Sofikitis; Ioannis Sokolakis; Vineet Malhotra; Sakti Ronggowardhana Brodjonegoro; Ricky Adriansjah; Akira Tsujimura; Toshiyasu Amano; Giancarlo Balercia; Imad Ziouziou; Isaac Ardianson Deswanto; Marlon Martinez; Hyun Jun Park; Mustafa Emre Bakırcıoglu; Erman Ceyhan; Kaan Aydos; Jonathan Ramsay; Suks Minhas; Manaf Al Hashimi; Ramy Abou Ghayda; Nicholas Tadros; Puneet Sindhwani; Christopher C.K. Ho; Rinaldo Indra Rachman; Marcelo Rodriguez Pena; Ahmad Motawi; Arun Karthik Ponnusamy; Satish Dipankar; Azwar Amir; Saleh Binsaleh; Ege Can Serefoglu; Ravi Banthia; Kareim Khalafalla; Ari Basukarno; Nguyen Hoai Bac; Karun Singla; Rafael F. Ambar; Konstantinos Makarounis; Shivam Priyadarshi; Gede Wirya Kusuma Duarsa; Widi Atmoko; Sunil Jindal; Eko Arianto; Hamed Akhavizadegan; Haitham El Bardisi; Ohad Shoshany; Gian Maria Busetto; Mohamad Moussa; Mounir Jamali; Mohamed S. Al-Marhoon; Mikhail Ruzaev; Hasan M. A. Farsi; Shingai Mutambirwa; Dong Sup Lee; Deniz Kulaksiz; Yu-Sheng Cheng; Abderrazak Bouzouita; Selcuk Sarikaya; Hussein Kandil; Georgios Tsampoukas; Ala’a Farkouh; Kasonde Bowa; Missy Savira; Nasser Mogharabian; Tan V. Le; Maruto Harjanggi; Dang Tuan Anh; Tran Quang Tien Long; Mohammad Ayodhia Soebadi; Lukman Hakim; Marko Tanic; Umut Cagin Ari; Firuza R. Parikh; Gokhan Calik; Vinod KV; Gyem Dorji; Andri Rezano; Osvaldo Rajmil; Dung Mai Ba Tien; Yiming Yuan; Juan Francisco Lizarraga-Salas; Balantine Eze; Kay Seong Ngoo; Joe Lee; Umut Arslan; Ashok Agarwal
Source
The World Journal of Men's Health, Vol 42, Iss 1, Pp 92-132 (2024)
Subject
Language
English
ISSN
2287-4208
2287-4690
2287-4690
Abstract
Purpose: The purpose of this meta-analysis is to study the impact of varicocele repair in the largest cohort of infertile males with clinical varicocele by including all available studies, with no language restrictions, comparing intra-person conventional semen parameters before and after the repair of varicoceles. Materials and Methods: The meta-analysis was performed according to PRISMA-P and MOOSE guidelines. A systematic search was performed in Scopus, PubMed, Cochrane, and Embase databases. Eligible studies were selected according to the PICOS model (Population: infertile male patients with clinical varicocele; Intervention: varicocele repair; Comparison: intraperson before-after varicocele repair; Outcome: conventional semen parameters; Study type: randomized controlled trials [RCTs], observational and case-control studies). Results: Out of 1,632 screened abstracts, 351 articles (23 RCTs, 292 observational, and 36 case-control studies) were included in the quantitative analysis. The before-and-after analysis showed significant improvements in all semen parameters after varicocele repair (except sperm vitality); semen volume: standardized mean difference (SMD) 0.203, 95% CI: 0.129–0.278; p