학술논문
Genomic Epidemiology of Severe Acute Respiratory Syndrome Coronavirus 2, Colombia
Document Type
article
Author
Katherine Laiton-Donato; Christian Julián Villabona-Arenas; José A. Usme-Ciro; Carlos Franco-Muñoz; Diego A. Álvarez-Díaz; Liz Stephany Villabona-Arenas; Susy Echeverría-Londoño; Zulma M. Cucunubá; Nicolás D. Franco-Sierra; Astrid C. Flórez; Carolina Ferro; Nadim J. Ajami; Diana Marcela Walteros; Franklin Prieto; Carlos Andrés Durán; Martha Lucia Ospina-Martínez; Marcela Mercado-Reyes
Source
Emerging Infectious Diseases, Vol 26, Iss 12, Pp 2854-2862 (2020)
Subject
Language
English
ISSN
1080-6040
1080-6059
1080-6059
Abstract
Coronavirus disease (COVID-19) in Colombia was first diagnosed in a traveler arriving from Italy on February 26, 2020. However, limited data are available on the origins and number of introductions of COVID-19 into the country. We sequenced the causative agent of COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), from 43 clinical samples we collected, along with another 79 genome sequences available from Colombia. We investigated the emergence and importation routes for SARS-CoV-2 into Colombia by using epidemiologic, historical air travel, and phylogenetic observations. Our study provides evidence of multiple introductions, mostly from Europe, and documents >12 lineages. Phylogenetic findings validate the lineage diversity, support multiple importation events, and demonstrate the evolutionary relationship of epidemiologically linked transmission chains. Our results reconstruct the early evolutionary history of SARS-CoV-2 in Colombia and highlight the advantages of genome sequencing to complement COVID-19 outbreak investigations.