학술논문
Immunosuppression is a risk factor for worse survival and disease‐specific death in cutaneous squamous cell carcinoma
Document Type
article
Author
Source
JEADV Clinical Practice, Vol 3, Iss 1, Pp 182-190 (2024)
Subject
Language
English
ISSN
2768-6566
Abstract
Abstract Background Previous literature on cutaneous squamous cell carcinoma (cSCC) suggests that the incidence, rate of metastasis, and tumour severity of cSCC are higher in immunosuppressed patients than in immunocompetent patients. However, current literature lacks an extensive comparison of cSCC clinical characteristics and outcomes in immunosuppressed patients. Objectives We compared cSCC tumour characteristics and disease‐related outcomes to help guide the clinical management of immunosuppressed patients. Methods We conducted a retrospective review of histopathologic and clinical data from 935 cSCC cases (19.5% immunosuppressed) from the Mayo Clinic. Results Immunosuppression was associated with younger age (69.3 vs. 74.8 years old, p