학술논문
Can circulating PD-1, PD-L1, BTN3A1, pan-BTN3As, BTN2A1 and BTLA levels enhance prognostic power of CA125 in patients with advanced high-grade serous ovarian cancer?
Document Type
article
Author
Daniele Fanale; Lidia Rita Corsini; Chiara Brando; Sofia Cutaia; Mariano Catello Di Donna; Clarissa Filorizzo; Maria Chiara Lisanti; Ugo Randazzo; Luigi Magrin; Raffaella Romano; Tancredi Didier Bazan Russo; Daniel Olive; Salvatore Vieni; Gianni Pantuso; Vito Chiantera; Antonio Russo; Viviana Bazan; Juan Lucio Iovanna
Source
Frontiers in Oncology, Vol 12 (2022)
Subject
Language
English
ISSN
2234-943X
Abstract
The most common subtype of ovarian cancer (OC) is the high-grade serous ovarian carcinoma (HGSOC), accounting for 70%–80% of all OC deaths. Although HGSOC is a potentially immunogenic tumor, clinical studies assessing the effectiveness of inhibitors of programmed death protein and its ligand (PD-1/PD-L1) in OC patients so far showed only response rates 401 U/ml and each soluble protein above respective concentration cutoff were covariates associated with shorter PFS (