학술논문
Changes in Invasive Pneumococcal Disease Caused by Streptococcus pneumoniae Serotype 1 following Introduction of PCV10 and PCV13: Findings from the PSERENADE Project
Document Type
article
Author
Julia C. Bennett; Marissa K. Hetrich; Maria Garcia Quesada; Jenna N. Sinkevitch; Maria Deloria Knoll; Daniel R. Feikin; Scott L. Zeger; Eunice W. Kagucia; Adam L. Cohen; Krow Ampofo; Maria-Cristina C. Brandileone; Dana Bruden; Romina Camilli; Jesús Castilla; Guanhao Chan; Heather Cook; Jennifer E. Cornick; Ron Dagan; Tine Dalby; Kostas Danis; Sara de Miguel; Philippe De Wals; Stefanie Desmet; Theano Georgakopoulou; Charlotte Gilkison; Marta Grgic-Vitek; Laura L. Hammitt; Markus Hilty; Pak-Leung Ho; Sanjay Jayasinghe; James D. Kellner; Jackie Kleynhans; Mirjam J. Knol; Jana Kozakova; Karl G. Kristinsson; Shamez N. Ladhani; Laura MacDonald; Grant A. Mackenzie; Lucia Mad’arová; Allison McGeer; Jolita Mereckiene; Eva Morfeldt; Tuya Mungun; Carmen Muñoz-Almagro; J. Pekka Nuorti; Metka Paragi; Tamara Pilishvili; Rodrigo Puentes; Samir K. Saha; Aalisha Sahu Khan; Larisa Savrasova; J. Anthony Scott; Anna Skoczyńska; Shigeru Suga; Mark van der Linden; Jennifer R. Verani; Anne von Gottberg; Brita A. Winje; Inci Yildirim; Khalid Zerouali; Kyla Hayford; the PSERENADE Team
Source
Microorganisms, Vol 9, Iss 4, p 696 (2021)
Subject
Language
English
ISSN
2076-2607
Abstract
Streptococcus pneumoniae serotype 1 (ST1) was an important cause of invasive pneumococcal disease (IPD) globally before the introduction of pneumococcal conjugate vaccines (PCVs) containing ST1 antigen. The Pneumococcal Serotype Replacement and Distribution Estimation (PSERENADE) project gathered ST1 IPD surveillance data from sites globally and aimed to estimate PCV10/13 impact on ST1 IPD incidence. We estimated ST1 IPD incidence rate ratios (IRRs) comparing the pre-PCV10/13 period to each post-PCV10/13 year by site using a Bayesian multi-level, mixed-effects Poisson regression and all-site IRRs using a linear mixed-effects regression (N = 45 sites). Following PCV10/13 introduction, the incidence rate (IR) of ST1 IPD declined among all ages. After six years of PCV10/13 use, the all-site IRR was 0.05 (95% credibility interval 0.04–0.06) for all ages, 0.05 (0.04–0.05) for