학술논문

The role of immune suppression in COVID-19 hospitalization: clinical and epidemiological trends over three years of SARS-CoV-2 epidemic
Document Type
article
Author
Marta CanutiMaria Cristina MontiChiara BobbioAntonio MuscatelloToussaint MuheberimanaSante Leandro BaldiFrancesco BlasiCiro CanettaGiorgio CostantinoAlessandro NobiliFlora PeyvandiMauro TettamantiSimone VillaStefano AlibertiMario C. RaviglioneAndrea GoriAlessandra BanderaCOVID-19 Network Study GroupBosari SilvanoScudeller LuigiaFusetti GiulianaRusconi LauraDell’Orto SilviaPrati DanieleValenti LucaGiovannelli SilviaManunta MariaLamorte GiuseppeFerarri FrancescaMangioni DavideAlagna LauraBozzi GiorgioLombardi AndreaUngaro RiccardoAncona GiuseppeZuglian GianlucaBolis MatteoIannotti NathalieLudovisi SerenaComelli AgneseRenisi GiuliaBiscarini SimonaCastelli ValeriaPalomba EmanueleFava MarcoFortina ValeriaLiparoti AriannaPastena AndreaAlberto Peri CarloSaltini PaolaViero GiuliaItri TeresaFerroni ValentinaPastore ValeriaMassafra RobertaCurri Maria TeresaRizzo AliceScarpa StefanoGiommi AlessandroBianco RosariaChitani Grazia ElianaGualtierotti RobertaFerrari BarbaraRossio RaffaellaBoasi NadiaPagliaro EricaMassimo CostanzaCaro Michele DeGiachi AndreaMontano NicolaVigone BarbaraBellocchi ChiaraCarandina AngelicaFiorelli ElisaMelli ValerieTobaldini EleonoraSpotti MauraTerranova LeonardoMisuraca SofiaD’Adda AliceFiore Silvia DellaPasquale Marta DiMantero MarcoContarini MartinaOri MargheritaMorlacchi LetiziaRossetti ValeriaGramegna AndreaPappalettera MariaCavallini MirtaBuscemi AgataVicenzi MarcoRota IrenaSolbiati MonicaFurlan LudovicoMancarella MartaColombo GiuliaColombo GiorgioFanin AlicePassarella MarieleMonzani ValterRovellini AngeloBarbetta LauraBilli FilippoFolli ChristianAccordino SilviaMaira DilettaHu Cinzia MariaMotta IreneScaramellini NataliaFracanzani Anna LudovicaLombardi RosaCespiati AnnalisaCesari MatteoLucchi TizianoProietti MarcoCalcaterra LauraMandelli ClaraCoppola CarlottaCerizza ArturoGrasselli GiacomoGalazzi AlessandroMonti IgorGalbusera Alessia Antonella
Source
Frontiers in Medicine, Vol 10 (2023)
Subject
SARS-CoV-2
COVID-19
disease outcome
hospitalization
COVID-19 vaccination
immune suppression
Medicine (General)
R5-920
Language
English
ISSN
2296-858X
Abstract
Specific immune suppression types have been associated with a greater risk of severe COVID-19 disease and death. We analyzed data from patients >17 years that were hospitalized for COVID-19 at the “Fondazione IRCCS Ca′ Granda Ospedale Maggiore Policlinico” in Milan (Lombardy, Northern Italy). The study included 1727 SARS-CoV-2-positive patients (1,131 males, median age of 65 years) hospitalized between February 2020 and November 2022. Of these, 321 (18.6%, CI: 16.8–20.4%) had at least one condition defining immune suppression. Immune suppressed subjects were more likely to have other co-morbidities (80.4% vs. 69.8%, p