학술논문
Electrocardiogram analysis in Anderson-Fabry disease: a valuable tool for progressive phenotypic expression tracking
Document Type
article
Author
V. Parisi; R. Baldassarre; V. Ferrara; R. Ditaranto; F. Barlocco; R. Lillo; F. Re; G. Marchi; C. Chiti; F. Di Nicola; C. Catalano; L. Barile; M. A. Schiavo; A. Ponziani; G. Saturi; A. G. Caponetti; A. Berardini; M. Graziosi; F. Pasquale; I. Salamon; M. Ferracin; E. Nardi; I. Capelli; D. Girelli; J. R. Gimeno Blanes; M. Biffi; N. Galiè; I. Olivotto; F. Graziani; E. Biagini
Source
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Subject
Language
English
ISSN
2297-055X
Abstract
BackgroundElectrocardiogram (ECG) has proven to be useful for early detection of cardiac involvement in Anderson-Fabry disease (AFD); however, little evidence is available on the association between ECG alterations and the progression of the disease.Aim and MethodsTo perform a cross sectional comparison of ECG abnormalities throughout different left ventricular hypertrophy (LVH) severity subgroups, providing ECG patterns specific of the progressive AFD stages. 189 AFD patients from a multicenter cohort underwent comprehensive ECG analysis, echocardiography, and clinical evaluation.ResultsThe study cohort (39% males, median age 47 years, 68% classical AFD) was divided into 4 groups according to different degree of left ventricular (LV) thickness: group A ≤ 9 mm (n = 52, 28%); group B 10–14 mm (n = 76, 40%); group C 15–19 mm (n = 46, 24%); group D ≥ 20 mm (n = 15, 8%). The most frequent conduction delay was right bundle branch block (RBBB), incomplete in groups B and C (20%,22%) and complete RBBB in group D (54%, p