부산대학교 도서관

Introduction: Roux-en-Y gastric bypass substantially alters the gut microbial composition which could be associated with the metabolic improvements seen after surgery. Few studies have been conducted in Latin American populations, such as Mexico where obesity prevalence is above 30% in the adult population. Thus, the aim of this study was to characterize the changes in gut microbiota structure in a Mexican cohort before and after Roux-en-Y gastric bypass and to explore whether surgery-related changes in the microbial community were associated with weight loss. Methods: Biological samples from patients who underwent Roux-en-Y gastric bypass were examined before and 12 months after surgery. Fecal microbiota characterization was performed through 16S rRNA sequencing. Results: Twenty patients who underwent Roux-en-Y gastric bypass showed a median excess weight loss of 66.8% 12 months after surgery. Surgery increased alpha diversity estimates (Chao, Shannon index and observed operational taxonomic units (OTUs), p