학술논문
Lymph node ratio is a more robust predictor of overall survival than N stage in stage III colorectal adenocarcinoma
Document Type
article
Author
Source
Diagnostic Pathology, Vol 19, Iss 1, Pp 1-9 (2024)
Subject
Language
English
ISSN
1746-1596
Abstract
Abstract Background Lymph node ratio (LNR) may offer superior prognostic stratification in colorectal adenocarcinoma compared with N stage. However, candidate cutoff ratios require validation. We aimed to study the prognostic significance of LNR and its optimal cutoff ratio. Methods We reviewed the pathology records of all patients with stage III colorectal adenocarcinoma who were managed at the King Hussein Cancer Center between January 2014 and December 2019. We then studied the clinical characteristics of the patients, correlates of lymph node count, prognostic significance of positive lymph nodes, and value of sampling additional lymph nodes. Results Among 226 included patients, 94.2% had ≥ 12 lymph nodes sampled, while 5.8% had