학술논문
The transcription factor DDIT3 is a potential driver of dyserythropoiesis in myelodysplastic syndromes
Document Type
article
Author
Nerea Berastegui; Marina Ainciburu; Juan P. Romero; Paula Garcia-Olloqui; Ana Alfonso-Pierola; Céline Philippe; Amaia Vilas-Zornoza; Patxi San Martin-Uriz; Raquel Ruiz-Hernández; Ander Abarrategi; Raquel Ordoñez; Diego Alignani; Sarai Sarvide; Laura Castro-Labrador; José M. Lamo-Espinosa; Mikel San-Julian; Tamara Jimenez; Félix López-Cadenas; Sandra Muntion; Fermin Sanchez-Guijo; Antonieta Molero; Maria Julia Montoro; Bárbara Tazón; Guillermo Serrano; Aintzane Diaz-Mazkiaran; Mikel Hernaez; Sofía Huerga; Findlay Bewicke-Copley; Ana Rio-Machin; Matthew T. Maurano; María Díez-Campelo; David Valcarcel; Kevin Rouault-Pierre; David Lara-Astiaso; Teresa Ezponda; Felipe Prosper
Source
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Myelodysplastic syndromes (MDS) are age-related pathologies in which alterations of hematopoietic stem cells lead to abnormal formation of blood cells. Here, the authors study the lesions that these cells undergo in aging and disease, characterizing a factor whose alteration in MDS leads to abnormal blood cell production.