학술논문
SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate
Document Type
article
Author
David Olagnier; Ensieh Farahani; Jacob Thyrsted; Julia Blay-Cadanet; Angela Herengt; Manja Idorn; Alon Hait; Bruno Hernaez; Alice Knudsen; Marie Beck Iversen; Mirjam Schilling; Sofie E. Jørgensen; Michelle Thomsen; Line S. Reinert; Michael Lappe; Huy-Dung Hoang; Victoria H. Gilchrist; Anne Louise Hansen; Rasmus Ottosen; Camilla G. Nielsen; Charlotte Møller; Demi van der Horst; Suraj Peri; Siddharth Balachandran; Jinrong Huang; Martin Jakobsen; Esben B. Svenningsen; Thomas B. Poulsen; Lydia Bartsch; Anne L. Thielke; Yonglun Luo; Tommy Alain; Jan Rehwinkel; Antonio Alcamí; John Hiscott; Trine H. Mogensen; Søren R. Paludan; Christian K. Holm
Source
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Viral infections usually cause disease through direct cytopathogenic effects and excessive inflammatory responses. Here, Olagnier et al. show that two NRF2 agonists, 4-OI and DMF, possess broad IFN-independent antiviral activity and decrease host inflammatory response to SARS-CoV-2 infection.