학술논문
Progressive loss of corneal nerve fibers is associated with physical inactivity and glucose lowering medication associated with weight gain in type 2 diabetes
Document Type
article
Author
Georgios Ponirakis; Ibrahim Al‐Janahi; Einas Elgassim; Hoda Gad; Ioannis N Petropoulos; Adnan Khan; Hamda Ali; Mashhood A Siddique; Wajiha Gul; Maryam Ferdousi; Alise Kalteniece; Fatima FS Mohamed; Lina HM Ahmed; Youssra Dakroury; Abeer MM El Shewehy; Abdulrahman Al‐Mohamedi; Fatema AlMarri; Moayad Homssi; Murtaza Qazi; Nebras H Hadid; Fatima Al‐Khayat; Ziyad R Mahfoud; Shazli Azmi; Uazman Alam; Mahmoud A Zirie; Yousuf Al‐Ansari; Amin Jayyousi; Alan S Rigby; Eric S Kilpatrick; Stephen L Atkin; Rayaz A Malik
Source
Journal of Diabetes Investigation, Vol 13, Iss 10, Pp 1703-1710 (2022)
Subject
Language
English
ISSN
2040-1124
2040-1116
2040-1116
Abstract
Abstract Aims/Introduction Limited studies have identified risk factors linked to the progression of diabetic peripheral neuropathy (DPN) in type 2 diabetes. This study examined the association of risk factors with change in neuropathy measures over 2 years. Materials and Methods Participants with type 2 diabetes (n = 78) and controls (n = 26) underwent assessment of clinical and metabolic parameters and neuropathy using corneal confocal microscopy (CCM), vibration perception threshold (VPT), and the DN4 questionnaire at baseline and 2 year follow‐up. Results Participants with type 2 diabetes had a lower corneal nerve fiber density (CNFD), branch density (CNBD), and fiber length (CNFL) (P ≤ 0.0001) and a higher VPT (P ≤ 0.01) compared with controls. Over 2 years, despite a modest reduction in HbA1c (P ≤ 0.001), body weight (P ≤ 0.05), and LDL (P ≤ 0.05) the prevalence of DPN (P = 0.28) and painful DPN (P = 0.21) did not change, but there was a significant further reduction in CNBD (P ≤ 0.0001) and CNFL (P ≤ 0.05). CNFD, CNBD, and CNFL decreased significantly in physically inactive subjects (P