학술논문
A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase
Document Type
article
Author
Ashleigh Shannon; Véronique Fattorini; Bhawna Sama; Barbara Selisko; Mikael Feracci; Camille Falcou; Pierre Gauffre; Priscila El Kazzi; Adrien Delpal; Etienne Decroly; Karine Alvarez; Cécilia Eydoux; Jean-Claude Guillemot; Adel Moussa; Steven S. Good; Paolo La Colla; Kai Lin; Jean-Pierre Sommadossi; Yingxiao Zhu; Xiaodong Yan; Hui Shi; François Ferron; Bruno Canard
Source
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
The drug AT-527 targets the SARS-CoV-2 replication machinery. Here the authors use Cryo-EM to show how AT-527 inhibits SARS-CoV-2 polymerase by acting as an immediate RNA chain terminator and stably binding in a NiRAN active-site pocket; impeding an essential nucleotide-transfer activity.