학술논문
A NOTCH feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma
Document Type
article
Author
Tim van Groningen; Nurdan Akogul; Ellen M. Westerhout; Alvin Chan; Nancy E. Hasselt; Danny A. Zwijnenburg; Marloes Broekmans; Peter Stroeken; Franciska Haneveld; Gerrit K. J. Hooijer; C. Dilara Savci-Heijink; Arjan Lakeman; Richard Volckmann; Peter van Sluis; Linda J. Valentijn; Jan Koster; Rogier Versteeg; Johan van Nes
Source
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
Neuroblastoma includes adrenergic and mesenchymal cell types that can interconvert. Here, the authors show that this transdifferentiation is driven by a NOTCH feedforward loop that allows a swift transition between two semi-stable cellular states.