학술논문
Multispectral optoacoustic tomography enables assessment of disease activity in paediatric inflammatory bowel disease
Document Type
article
Author
Adrian P. Regensburger; Markus Eckstein; Matthias Wetzl; Roman Raming; Lars-Philip Paulus; Adrian Buehler; Emmanuel Nedoschill; Vera Danko; Jörg Jüngert; Alexandra L. Wagner; Alexander Schnell; Aline Rückel; Ulrich Rother; Oliver Rompel; Michael Uder; Arndt Hartmann; Markus F. Neurath; Joachim Woelfle; Maximilian J. Waldner; André Hoerning; Ferdinand Knieling
Source
Photoacoustics, Vol 35, Iss , Pp 100578- (2024)
Subject
Language
English
ISSN
2213-5979
Abstract
Multispectral optoacoustic tomography (MSOT) allows non-invasive molecular disease activity assessment in adults with inflammatory bowel disease (IBD). In this prospective pilot-study, we investigated, whether increased levels of MSOT haemoglobin parameters corresponded to inflammatory activity in paediatric IBD patients, too. 23 children with suspected IBD underwent MSOT of the terminal ileum and sigmoid colon with standard validation (e.g. endoscopy). In Crohn`s disease (CD) and ulcerative colitis (UC) patients with endoscopically confirmed disease activity, MSOT total haemoglobin (HbT) signals were increased in the terminal ileum of CD (72.1 ± 13.0 a.u. vs. 32.9 ± 15.4 a.u., p = 0.0049) and in the sigmoid colon of UC patients (62.9 ± 13.8 a.u. vs. 35.1 ± 16.3 a.u., p = 0.0311) as compared to controls, respectively. Furthermore, MSOT haemoglobin parameters correlated well with standard disease activity assessment (e.g. SES-CD and MSOT HbT (rs =0.69, p = 0.0075). Summarizing, MSOT is a novel technology for non-invasive molecular disease activity assessment in paediatric patients with inflammatory bowel disease.