학술논문
Pharmacodynamic monitoring by residual gene expression of the nuclear factor of activated T cell-regulated genes in lung transplant recipients and its correlation with tacrolimus blood levels
Document Type
article
Author
Meritxell Boada-Pérez; Victoria Ruiz de Miguel; Marta Erro; Piedad Ussetti; Myriam Aguilar; Raquel Castejón; Silvia Rosado; Roser Escobar-Fornieles; Eva Revilla-López; Carlos Bravo; Berta Sáez-Giménez; Marta Zapata-Ortega; Yolanda Villena-Ortiz; Jaume Vima-Bofarull; Víctor Monforte; Susana Gómez-Ollés
Source
Frontiers in Immunology, Vol 15 (2024)
Subject
Language
English
ISSN
1664-3224
Abstract
IntroductionTrough blood levels (C0) of tacrolimus are used to adjust drug dosage, but they do not consistently correlate with clinical outcomes. Measurement of residual gene expression of nuclear factor of activated T cell (NFAT)-regulated genes (NFAT-RGE) has been proposed as a pharmacodynamic biomarker to assess the degree of immunosuppression in certain solid organ transplantations, but little is known regarding lung transplant recipients (LTR). Our primary objective is to correlate tacrolimus blood levels with NFAT-RGE.MethodsNFAT-RGE and tacrolimus C0 and peak (C1.5) levels were determined in 42 patients at three, six and 12 months post-transplantation.ResultsTacrolimus C0 did not exhibit a correlation with NFAT-RGE, whereas C1.5 did. Besides, over 20% of measurements indicated high levels of immunosuppression based on the below 30% NFAT-RGE threshold observed in many studies. Among those measurements within the therapeutic range, 19% had an NFAT-RGE