학술논문
Household air pollution and risk of pulmonary tuberculosis in HIV-Infected adults
Document Type
article
Author
Patrick D.M.C. Katoto; Dieudonné Bihehe; Amanda Brand; Raymond Mushi; Aline Kusinza; Brian W. Alwood; Richard N. van Zyl-Smit; Jacques L. Tamuzi; Nadia A. Sam-Agudu; Marcel Yotebieng; John Metcalfe; Grant Theron; Krystal J. Godri Pollitt; Maia Lesosky; Jeroen Vanoirbeek; Kevin Mortimer; Tim Nawrot; Benoit Nemery; Jean B. Nachega
Source
Environmental Health, Vol 23, Iss 1, Pp 1-16 (2024)
Subject
Language
English
ISSN
1476-069X
Abstract
Abstract Background In low- and middle-income countries countries, millions of deaths occur annually from household air pollution (HAP), pulmonary tuberculosis (PTB), and HIV-infection. However, it is unknown whether HAP influences PTB risk among people living with HIV-infection. Methods We conducted a case-control study among 1,277 HIV-infected adults in Bukavu, eastern Democratic Republic of Congo (February 2018 – March 2019). Cases had current or recent (3h/day and ≥2 times/day and ≥5 days/week were more likely to have PTB (aOR 1·36; 95%CI 1·06-1·75) than those spending less time in the kitchen. Time-weighted average 24h personal CO exposure was related dose-dependently with the likelihood of having PTB, with aOR 4·64 (95%CI 1·1-20·7) for the highest quintile [12·3-76·2 ppm] compared to the lowest quintile [0·1-1·9 ppm]. Conclusion Time spent cooking and personal CO exposure were independently associated with increased risk of PTB among people living with HIV. Considering the high burden of TB-HIV coinfection in the region, effective interventions are required to decrease HAP exposure caused by cooking with biomass among people living with HIV, especially women.