학술논문
A retrospective analysis of ezrin protein and mRNA expression in breast cancer: Ezrin expression is associated with patient survival and survival of patients with receptor‐positive disease
Document Type
article
Author
Source
Cancer Medicine, Vol 12, Iss 9, Pp 10908-10916 (2023)
Subject
Language
English
ISSN
2045-7634
97080691
97080691
Abstract
Abstract Introduction The cytoskeletal protein ezrin is upregulated in many cancer types and is strongly associated with poor patient outcome. While the clinical and prognostic value of ezrin has been previously evaluated in breast cancer, most studies to date have been conducted in smaller cohorts (less than 500 cases) or have focused on specific disease characteristics. The current study is the largest of its kind to evaluate ezrin both at the protein and mRNA levels in early‐stage breast cancer patients using the Nottingham (n = 1094) and METABRIC (n = 1980) cohorts, respectively. Results High expression of ezrin was significantly associated with larger tumour size (p = 0.027), higher tumour grade (p