학술논문
Multifactorial seroprofiling dissects the contribution of pre-existing human coronaviruses responses to SARS-CoV-2 immunity
Document Type
article
Author
Irene A. Abela; Chloé Pasin; Magdalena Schwarzmüller; Selina Epp; Michèle E. Sickmann; Merle M. Schanz; Peter Rusert; Jacqueline Weber; Stefan Schmutz; Annette Audigé; Liridona Maliqi; Annika Hunziker; Maria C. Hesselman; Cyrille R. Niklaus; Jochen Gottschalk; Eméry Schindler; Alexander Wepf; Urs Karrer; Aline Wolfensberger; Silvana K. Rampini; Patrick M. Meyer Sauteur; Christoph Berger; Michael Huber; Jürg Böni; Dominique L. Braun; Maddalena Marconato; Markus G. Manz; Beat M. Frey; Huldrych F. Günthard; Roger D. Kouyos; Alexandra Trkola
Source
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
How the immune responses induced by SARS-CoV-2 and human coronavirus (hCoV) crosstalk is still unclear. Here the authors profile the humoral responses of prepandemic and SARS-CoV-2-infected donors to find that higher hCoV antibody titers are associated with SARS-CoV-2 negativity, and with reduced hospitalization in SARS-CoV-2 positive patients.