학술논문
Self-Amplifying RNA Vaccine Candidates: Alternative Platforms for mRNA Vaccine Development
Document Type
article
Author
Source
Pathogens, Vol 12, Iss 1, p 138 (2023)
Subject
Language
English
ISSN
12010138
2076-0817
2076-0817
Abstract
The present use of mRNA vaccines against COVID-19 has shown for the first time the potential of mRNA vaccines for infectious diseases. Here we will summarize the current knowledge about improved mRNA vaccines, i.e., the self-amplifying mRNA (saRNA) vaccines. This approach may enhance antigen expression by amplification of the antigen-encoding RNA. RNA design, RNA delivery, and the innate immune responses induced by RNA will be reviewed.