학술논문
Oligomerization, trans-reduction, and instability of mutant NOTCH3 in inherited vascular dementia
Document Type
article
Author
Source
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Subject
Language
English
ISSN
2399-3642
Abstract
Specific cysteine residue alterations and quaternary structures are induced by CADASIL mutations in NOTCH3, which are found to induce oligomeric states, altered disulphide bonding, increased free thiols and reduced protein stability.