학술논문
Human alveolar progenitors generate dual lineage bronchioalveolar organoids
Document Type
article
Author
Karen Hoffmann; Benedikt Obermayer; Katja Hönzke; Diana Fatykhova; Zeynep Demir; Anna Löwa; Luiz Gustavo Teixeira Alves; Emanuel Wyler; Elena Lopez-Rodriguez; Maren Mieth; Morris Baumgardt; Judith Hoppe; Theresa C. Firsching; Mario Tönnies; Torsten T. Bauer; Stephan Eggeling; Hong-Linh Tran; Paul Schneider; Jens Neudecker; Jens C. Rückert; Achim D. Gruber; Matthias Ochs; Markus Landthaler; Dieter Beule; Norbert Suttorp; Stefan Hippenstiel; Andreas C. Hocke; Mirjana Kessler
Source
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
Subject
Language
English
ISSN
2399-3642
Abstract
The GSK3 inhibitor CHIR99021 is required to maintain the alveolar lineage in alveolar progenitors grown in airway media or AT2 cells become plastic, with the observed effects acting outside of its role as a GSK3B inhibitor.