학술논문
Caffeine intervention after abstinence does not alter cognitive parameters in premenstrual syndrome women regardless of CYP1A2 genotype
Document Type
article
Author
Renata Lira de Assis; Caroline Severo de Assis; Tainá Gomes Diniz; Bruno Rafael Virginio de Sousa; Carla Alexandra da Silva Moita Minervino; Matheus Lima de Paiva; Vinícius José Baccin Martins; Enéas Ricardo de Morais Gomes; Marcelo Felipe Rodrigues da Silva; Yuri Mangueira Nascimento; Evandro Ferreira da Silva; Josean Fechine Tavares; Darlene Camati Persuhn
Source
Journal of Functional Foods, Vol 115, Iss , Pp 106101- (2024)
Subject
Language
English
ISSN
1756-4646
Abstract
This study aimed to evaluate the effect of caffeine on cognitive parameters in premenstrual syndrome women of childbearing age undergoing caffeine withdrawal, observing the influence of cytochrome P450 enzyme isozyme 1A2 genotypes. This is a crossover study with 26 women (all participants) grouped according to genotype (17 AA and 9 AC/CC). The cognitive assessment was carried out before and after caffeine or placebo. A significant increase in attention was showed both after placebo and caffeine administration, however, no statistical difference was observed between caffeine and placebo groups. This occurred both for all participants and in the genotype groups. Working memory was improved for all participants, and in the AC/CC group after placebo ingestion; the same did not occur after caffeine intake. In the AA group, no significant changes were observed for placebo or caffeine. Caffeine does not promote effects on cognitive performance in premenstrual syndrome women after caffeine abstinence.