학술논문

Single Cell Atlas: a single-cell multi-omics human cell encyclopedia
Document Type
article
Source
Genome Biology, Vol 25, Iss 1, Pp 1-21 (2024)
Subject
Single-cell omics
Multi-omics
Single Cell Atlas
Human database
Single-cell RNA-sequencing
Spatial transcriptomics
Biology (General)
QH301-705.5
Genetics
QH426-470
Language
English
ISSN
1474-760X
Abstract
Abstract Single-cell sequencing datasets are key in biology and medicine for unraveling insights into heterogeneous cell populations with unprecedented resolution. Here, we construct a single-cell multi-omics map of human tissues through in-depth characterizations of datasets from five single-cell omics, spatial transcriptomics, and two bulk omics across 125 healthy adult and fetal tissues. We construct its complement web-based platform, the Single Cell Atlas (SCA, www.singlecellatlas.org ), to enable vast interactive data exploration of deep multi-omics signatures across human fetal and adult tissues. The atlas resources and database queries aspire to serve as a one-stop, comprehensive, and time-effective resource for various omics studies.