학술논문
Blocking phospholamban with VHH intrabodies enhances contractility and relaxation in heart failure
Document Type
article
Author
Erwin De Genst; Kylie S. Foo; Yao Xiao; Eduarde Rohner; Emma de Vries; Jesper Sohlmér; Nevin Witman; Alejandro Hidalgo; Terje R. S. Kolstad; William E. Louch; Susanne Pehrsson; Andrew Park; Yasuhiro Ikeda; Xidan Li; Lorenz M. Mayr; Kate Wickson; Karin Jennbacken; Kenny Hansson; Regina Fritsche-Danielson; James Hunt; Kenneth R. Chien
Source
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Here the authors use modified RNA and VHH libraries to generate intrabodies that target dysregulated interactions between two calcium handling proteins in failing cardiomyocytes. Heart specific expression of the intrabodies in a murine heart failure model results in improved cardiac function.