부산대학교 도서관

Eun Hyung Yoo,1 Hyo-Lim Hong,2 Eun Jin Kim2 1Department of Laboratory Medicine, Daegu Catholic University School of Medicine, Daegu, Korea; 2Department of Internal Medicine, Daegu Catholic University School of Medicine, Daegu, KoreaCorrespondence: Eun Jin Kim, Department of Internal Medicine, Daegu Catholic University School of Medicine, 33, Duryugongwon-ro 17gil, Namgu, Daegu, 42472, Korea, Tel +82-53-650-4274, Fax +82-53-650-4942, Email ejkim77@cu.ac.krPurpose: The prevalence of carbapenem-resistant Enterobacterales (CRE) is rapidly increasing worldwide. Patients in the intensive care unit (ICU) are susceptible to CRE infections, and the related mortality rate is increased. It is necessary to understand CRE strains and risk factors for CRE infection in the ICU, to facilitate development of effective prophylactic strategies and treatments for ICU patients.Patients and Methods: This observational study was conducted in a tertiary hospital between 2016 and 2021. The subjects were patients with CRE cultured from specimens obtained after ICU admission. Genotypes of strains of CRE and carbapenemase-producing Enterobacterales (CPE) were identified, CRE infection was distinguished from mere colonization, and the clinical course of these patients was investigated.Results: Among 327 CRE cases, 84 (25.7%) showed infection and 243 (74.3%) showed colonization. Of these patients, 138 (42.2%) died. The CRE strains were Klebsiella pneumoniae (253 cases, 77.4%), Enterobacter cloacae (44 cases, 13.5%), and Escherichia coli (15 cases, 4.6%). Among CRE cases, CPE was found in 249 (76.1%), including Klebsiella pneumoniae carbapenemase (KPC) in 164 (65.9%), and Guiana extended-spectrum (GES) in 64 (25.7%). A bedridden state, longer ICU stay, chronic kidney disease, malignancy, connective tissue disease, ICU admission for cardiac arrest, and CRE infection were associated with higher mortality, but cerebrovascular disease and ICU admission for trauma were associated with lower mortality. GES outbreak was caused by person-to-person transmission and was controlled through active surveillance.Conclusion: The frequency of K. pneumoniae and KPC was the highest, but E. cloacae and GES was characteristically high in this study. Active CRE surveillance can be helpful for controlling outbreak.Keywords: carbapenemase-producing Enterobacterales, genotypes, intensive care unit, Klebsiella pneumoniae carbapenemase, Guiana extended spectrum